Stroke: People at Risk and its Consequences

"Stroke" is a the common term for an "acute cerebral infarction", which means injury with loss of neurons of the brain tissue. There are 2 main causes for stroke: the obstruction of one of the arteries that feeds blood to the brain and bleeding from blood vessels in the brain. Both situations are very serious and can lead to loss of brain cells, loss of physical or intellectual function and death.

The people who are at risk for stroke are diabetics, people with high blood pressure, smokers, obese and patients with high cholesterol. If someone already has had a stroke he or she has a higher risk to have another one. In addition, for an individual who has coronary artery disease or peripheral artery disease, there is an increased risk of stroke. Atrial fibrillation (AF; an irregular heart beat) increases the chances of stroke, that is the reason why many persons with AF have to take an anticoagulant (blood thinner). Finally, there are genetic conditions that can increase the risk of stroke. Examples of this are sickle cell disease and increased coagulation disorders such as Factor V Leyden.

Stroke can be a devastating condition for the individual and it is definitely a major public health problem¹ due to the immense cost it represents. It accounts for approximately 320 billion dollars every year in healthcare direct and indirect expenditures². The patient has to deal with loss of function, which could be physical  (paralysis of arms, legs and/or face), and intellectual deficits like the loss memory and inability to speak. The recovery from stroke is usually slow and involves the use different levels of rehabilitation services.

References

1. Hankey GJ. StrokeHow Large a Public Health Problem, and How Can the Neurologist Help?. Arch Neurol. 1999;56(6):748-754. 

2. Mozaffarian D, Benjamin EJ, Go AS, et al. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation. 2016;133:e38-e360.

Marco A. Ramos MD

Documenting Malnutrition. Part 4

The Physical Exam (PE) in Severe Malnutrition in the Setting of  Acute Illness

The presence of physical findings of malnutrition in the setting of acute illness is more difficult to find than in the typically malnourished chronically ill patient. Because of this, the criteria are less strict. In addition, there is the complication that most likely we do not know the premorbid condition of a patient so it would be difficult to assess the loss of muscle mass or the loss of adipose tissue. 

In order to assess the adipose tissue loss, we have to look for the following regions of the body:

- The periorbital region

- The triceps region for the triceps skin fold

- The ribcage region

When we assess the periorbital region we look for how sunken the eyes look in the orbital cavity. When we assess the tricipital fold, we see how much tissue can our fingers grab when we separate the triceps muscle from the skin and subcutaneous  tissue and when we examine the ribcage, we assess how prominent the rib bones look. 

The ASPEN criteria to determine severity of the malnutrition are very subjective. For example, in order to diagnose non-severe malnutrition in the setting of acute illness the adipose tissue loss in the mentioned regions has to be “mild”. In order to diagnose severe malnutrition in the setting of acute illness, the adipose tissue loss has to be at least “moderate”.

When we evaluate the muscle tissue loss we have to look to the following regions of the body:

- The temporal region (temples)

- The supraclavicular region (clavicles)

- The interosseous region in the hands

- The shoulder region

- The scapula region

- The thigh region.

- The calf region

Again, the ASPEN criteria are very subjective and in this case, what we are looking for is how depressed the hollow in the temporal region may be and how prominent the bony structures may look in all the other regions. The muscle size of the thighs and calves can also be assessed subjectively. In order to diagnose non-severe malnutrition in the setting of acute illness the muscle tissue loss in the mentioned regions has to be “mild”. In order to diagnose severe malnutrition in the setting of acute illness, the muscle tissue loss has to be at least “moderate”.

So, a PE may read like this:

“Mr A is a 58 year old gentleman who presented to the emergency department (ED) with a history of nausea, vomiting and abdominal pain for 5 days.

HENT: Eyes look moderately sunken in orbital cavity

Musculoskeletal: Moderately hollow temporal areas, moderately reduced muscle mass of interosseous muscles of the hands. Moderately reduced skin fold at the level of the triceps. Ribcage shows moderately marked ribs. 

Marco A. Ramos MD

Second Medical Opinions PLC

Physician Advisor in Clinical Documentation Improvement

What is COPD? Who has it?

COPD stands for Chronic Obstructive Pulmonary Disease. There are 2 main conditions that are associated with COPD. The first condition is emphysema (the most common) and the second condition is chronic bronchitis. Smoking tobacco is the most common cause for COPD, although there are relatively rare genetic conditions that lead to similar changes without the influence of smoking cigarettes.

The term “chronic” represents that the anatomical changes in the lungs become fixed and may not reverse, although stopping smoking will certainly slow down the progression towards oxygen dependency. The term “obstructive” refers to the loss in elastic recoil of the lung tissue that will prevent the airways to be sufficiently opened at the time of exhaling air. This causes functional obstruction and air to be trapped in the lungs.

COPD can be a seriously debilitating condition. In its more severe form, it leads to the need of oxygen supplementation for the patient. In addition, a person with COPD is more prone to lung infections and even minor viral illnesses can cause acute respiratory failure. This can cause the need for intensive care and mechanical ventilation.

As it was mentioned before, smoking tobacco is the main culprit for this condition. It is never too late to stop smoking. COPD progression may not be stopped but it may be slowed down significantly. There are several medications that can be used in order to treat symptoms and reduce the functional obstruction in the airways. A physician will help any patient regarding smoking cessation and the treatment of COPD.

Marco A. Ramos MD

Documenting Malnutrition Part 3

The History of Present Illness (HPI) in Severe Malnutrition in the Setting of  Chronic Illness

Chronic disease is frequently associated with malnutrition Examples of this are cancer, liver disease, malabsorption syndromes, heart failure, etc. In these cases, the process that ends in a patient being hospitalized is an acute problem such as an infection or an acute dysfunction of an organ system. The malnutrition is in the background, predisposing the patient to a worse outcome.  When these situations occur, the weight loss, the decline in appetite and the physical changes in the patient’s body are not taken into account by the patient or the family when they refer the history. Questioning properly becomes very important. The American Society for Parenteral and Enteral Nutrition (ASPEN) guidelines¹  states that in order to consider a patient having severe malnutrition in the setting of chronic illness, he or she has to consume less than 75% of the estimated energy requirement for at least 1 month. Since 2 criteria are needed, the requirement may be fulfilled by documenting weight loss or an aspect of the physical exam. Regarding the loss of weight criteria, ASPEN guidelines say that in order to consider a patient for having severe malnutrition in the setting of chronic illness, the loss of weight in 1 month has to be 5% or more. If the loss of weight happens in 3 month, it has to be 7.5% or more, if it happens in the preceding 6 months it has to be 10% or more and if it occurs in 1 year it has to be at least 20%

So, an HPI may read like this:

“Mrs Y is a 53 year old  lady who presented to the emergency department (ED) with a history of nausea, vomiting and diarrhea for 1 day. She was diagnosed with Crohn’s disease 5 years ago and in the past year she has had several flares. As an average, for the past month she has eaten only 50-70 % of her normal meals due to bloating and lack of appetite. In the past 6 months she has lost 15 pounds. She used to weigh 125 pounds. She presented to the ED because she was unable to keep any oral intake and she started to note a darker urine and a decrease in its volume”

Please note that the last piece of information can also be placed in the Review of Systems (ROS). The information in the HPI anticipates what is going to show in the Assessment and Plan (A/P)

References

1 http://www.baxternutritionacademy.com/ie/disease_related/identifying_malnutrition.html Retrieved December 13, 2016

Marco A. Ramos MD

Second Medical Opinions PLC

Physician Advisor in Clinical Documentation Improvement

Crohn’s Disease and its Complications

Crohn’s disease is an inflammatory disease of the bowel that can affect any part of the intestinal tract, from the mouth to the anus. It symptoms, may include abdominal pain, diarrhea, bloody stools, abdominal distention, and intestinal malabsorption.  It can also cause extra intestinal symptoms, such as fever, joint pain, skin rashes, eye problems and generalized fatigue.  Currently, it affects 0.32 percent of people in Europe and North America and its prevalence has been increasing over the past decades.

This condition is caused by a combination of genetic and environmental factors. There are several genes known to be strongly associated with the presence of Crohn’s disease¹. In addition, an environmental risk factors such as tobacco exposure, seems to be equally important. It is known that tobacco smokers are twice as likely to be affected by this entity than non smokers².

There are various degrees of severity for Crohn’s disease and it can be complicated by intestinal obstruction, fistula formation, gastrointestinal bleeding, intestinal perforation and abscesses. There is a higher risk of cancer in the areas of inflammation caused by Crohn’s disease. Due to the inflammatory nature of the condition, food malabsorption can develop leading to weight loss and malnutrition.

The treatment of Crohn’s disease has to include lifestyle changes such as stopping smoking and following dietary recommendations such as low dietary fiber, low casein and gluten free diet. In addition to this, there are certain medications that may be used for the exacerbations of the disease, such as steroids and some long term medications like methotrexate and biological therapies. At this point, the advise of a gastroenterologist is the most valuable tool.

Marco A. Ramos MD

References

1. Genome-wide association defines more than thirty distinct susceptibility loci for Crohn's disease. Barrett JC, Hansoul S, Dan L. Nicolae DL, et al. Nat Genet. 2008; 40(8): 955–962

2. Tobacco and IBD: Relevance in the understanding of disease mechanisms and clinical practice. Cosnes J. Best Pract Res Clin Gastroenterol. 2004; 8(3):481-96

Documenting Malnutrition. Part 2

The History of Present Illness (HPI) in Severe Malnutrition in the Setting of Acute Illness

Documenting malnutrition, specially in the acute setting is one of the most disregarded aspects in clinical documentation. Many acute disease processes that lead to hospitalization, are preceded by a reduction in the intake of food and/or loss of weight. For example, a patient who is diagnosed with pneumonia with septic shock, could have started the process one week prior to the admission with an upper respiratory tract infection and with loss of appetite. Due to the decline in oral intake, the patient could have lost some weight and some patients may track their own weight or there might be outpatient records showing previous weights when the patient was not having the acute illness. The American Society for Parenteral and Enteral Nutrition (ASPEN) guidelines¹  state that to consider a patient having severe malnutrition in the setting of acute illness, a reduction of more than 50% of the estimated energy requirement has to be present for 5 days or more. Since 2 criteria are needed, the requirement may be fulfilled by documenting weight loss or an aspect of the physical exam. Regarding the loss of weight criteria, ASPEN guidelines say that in order to consider a patient for having severe malnutrition in the setting of acute illness, the loss of weight in 1 week has to be 2% or more. If the loss of weight happens in a month, it has to be 5% or more and if it happens in the preceding 3 months it has to be 7.5% or more.

So, an HPI may read like this:

“Mr X is a 74 year old gentleman who presented to the emergency department (ED) with a history of 7 days of progressive productive cough, dyspnea, anorexia and fever. The patient referred that 7 days prior to presentation he developed “cold”. He said that his oral intake was reduced to about 25% of a normal meal. 3 days prior to admission, he developed productive cough with a green sputum and 2 days prior, high fever quantified at 102 F. Due to the symptoms getting progressively worse and the addition of dyspnea on mild efforts, he decided to show up in the ED. He stated that his usual weight is 150 pounds and now he is weight 145 pounds.”

Please note that the last piece of information can also be placed in the Review of Systems (ROS). The information in the HPI anticipates what is going to show in the Assessment and Plan (A/P)

References

1 http://www.baxternutritionacademy.com/ie/disease_related/identifying_malnutrition.html Retrieved January 12, 2017

Marco A. Ramos MD

Second Medical Opinions PLC

Physician Advisor in Clinical Documentation Improvement

Vitamin D and Cancer

In a previous post from January 27, 2016  (http://blog1.smopinions.com/2016/01/7-interesting-facts-about-vitamin-d.html), it was mentioned that there are associations between vitamin D deficiency and certain types of cancer. This post will explain a little bit more about them.

Regarding colorectal cancer, it was noticed about 2 decades ago, that there is more mortality from colorectal cancer in the northern and northeastern parts of the United States, the ones which receive less sunlight. This in itself is not enough to establish a meaningful association, however, it gave a starting point for research. Then, 2 studies showed that having levels above 30 ng/dL in the blood may reduce the incidence of colorectal cancer by half^1,2.

With respect to breast cancer, a recent study found that postmenopausal women may get a benefit from having adequate vitamin D levels in the blood. The risk of developing breast cancer in this particular group of women was lower than in the same group of women with lower vitamin D in their blood³.

Finally, in regards to prostate cancer, it has been found that this cancer is also more common in regions with less sun exposure. In addition, lower vitamin D levels in the blood are related to more aggressive forms of prostate cancer. Last but not least, adequate levels of vitamin D may aid in the slowing of the progression of this type of cancer⁴.

More research is needed in order to confirm and strengthen these associations. In the mean time, it does not hurt to have adequate levels of vitamin D in the blood, particularly for people living north of the 30th parallel.

References

1. Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Garland CF, Comstock GW, Garland FC, Helsing KJ, Shaw EK, Gorham ED. Lancet. 1989;2(8673):1176-8.

2. Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H. Alim Pharm Therap. 2009 30(2):113-25

3. Plasma vitamin D levels, menopause, and risk of breast cancer: dose-response meta-analysis of prospective studies. Bauer SR, Hankinson SE, Bertone-Johnson ER, Ding EL. Medicine (Baltimore). 2013;92(3):123-31

4. Association between serum 25(OH)D and death from prostate cancer. Tretli S, Hernes E, Berg JP, Hestvik UE, Robsahm TE. Br. J. Cancer 2009;100(3):450-4.

Marco A. Ramos MD